Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence
نویسندگان
چکیده
منابع مشابه
Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence
The major membrane phospholipid classes, described thus far, include phosphatidylcholine (PtdCho), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer), and phosphatidylinositol (PtdIns). Here, we demonstrate the natural occurrence and genetic origin of an exclusive and rather abundant lipid, phosphatidylthreonine (PtdThr), in a common eukaryotic model parasite, Toxoplasma gondii. The...
متن کاملParasite Virulence
Some parasites exact a terrible price from their hosts, causing severe pathology and reducing the host’s fitness, whereas other parasites are essentially benign. Several kinds of comparisons highlight this observation. Least interesting are comparisons of parasites with very different life histories or types of host tissues invaded (compare human immunodeficiency virus (HIV) and rhinovirus infe...
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Several evolutionary processes influence virulence, the amount of damage a parasite causes to its host. For example, parasites are favored to exploit their hosts prudently to prolong infection and avoid killing the host. Parasites also need to use some host resources to reproduce and transmit infections to new hosts. Thus parasites face a tradeoff between prudent exploitation and rapid reproduc...
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Parasite virulence evolution is shaped by both within-host and population-level processes yet the link between these differing scales of infection is often neglected. Population structure and heterogeneity in both parasites and hosts will affect how hosts are exploited by pathogens and the intensity of infection. Here, it is shown how the degree of relatedness among parasites together with epid...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2015
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1002288